Table 2. Multivariate Cox hazards regression analysis of CSS in the development cohort with UAC.
| Variables | HR | 95% CI | P value |
|---|---|---|---|
| Age (years) | |||
| ≤39 | Reference | ||
| 40–59 | 1.08 | 0.93–1.25 | 0.31 |
| ≥60 | 1.56 | 1.32–1.83 | <0.001*** |
| Race | |||
| White | Reference | ||
| Black | 1.31 | 1.11–1.55 | 0.001** |
| Other | 1.19 | 1.01–1.39 | 0.03* |
| Grade | |||
| Grade I | Reference | ||
| Grade II | 1.43 | 1.21–1.69 | <0.001*** |
| Grade III and IV | 2.09 | 1.77–2.47 | <0.001*** |
| Stage T | |||
| T1a | Reference | ||
| T1b | 3.86 | 2.52–5.91 | <0.001*** |
| T2 | 7.30 | 4.67–11.40 | <0.001*** |
| T3 | 10.81 | 6.81–17.14 | <0.001*** |
| T4 | 13.60 | 8.42–21.98 | <0.001*** |
| Stage N | |||
| N0 | Reference | ||
| N1 | 1.87 | 1.42–2.66 | <0.001*** |
| Stage M | |||
| M0 | Reference | ||
| M1 | 1.79 | 1.50–2.14 | <0.001*** |
| Surgery of primary site | |||
| No | Reference | ||
| Yes | 0.79 | 0.68–0.92 | 0.003** |
| Surgery of regional LNs | |||
| No | Reference | ||
| Yes | 1.02 | 0.84–1.23 | 0.88 |
| Surgery of distant metastasis | |||
| No | Reference | ||
| Yes | 0.84 | 0.64–1.11 | 0.221 |
| Radiation | |||
| No | Reference | ||
| Yes | 1.24 | 1.07–1.45 | 0.005** |
| Chemotherapy | |||
| No | Reference | ||
| Yes | 0.88 | 0.77–1.00 | 0.045* |
| Tumor size (mm) | |||
| ≤20 | Reference | ||
| 21–40 | 1.82 | 1.51–2.21 | <0.001*** |
| >40 | 2.21 | 1.81–2.69 | <0.001*** |
| Number of positive LNs | |||
| None | Reference | ||
| 1–3 | 2.27 | 0.72–7.10 | 0.16 |
| >3 | 2.16 | 0.68–6.80 | 0.189 |
| Number of LNs examined | |||
| None | Reference | ||
| 1–15 | 0.71 | 0.57–0.88 | 0.002** |
| 16–30 | 0.59 | 0.46–0.75 | <0.001*** |
| >30 | 0.60 | 0.45–0.79 | <0.001*** |
| Multi-primary tumors | |||
| One primary only | Reference | ||
| 1st of 2 or more primary tumors | 0.68 | 0.56–0.81 | <0.001*** |
*, two sided P values <0.05; **, two sided P values <0.01; ***, two sided P values <0.001. CSS, cancer-specific survival; UAC, uterine cervical adenocarcinoma; stage T, stage of primary tumor; stage N, stage of lymph nodes; stage M, stage of metastasis; LNs, lymph nodes; HR, hazard ratio; CI, confidence interval.