Table 3. Predictive factors for relapse-free survival by univariate and multivariate analysis in all patients.
| Characteristics | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| Age | |||||
| >65 vs. ≤65 years | 0.650 (0.343–1.232) | 0.186 | 0.780 (0.398–1.528) | 0.469 | |
| Gender | |||||
| Male vs. female | 0.926 (0.585–1.466) | 0.742 | 0.796 (0.488–1.299) | 0.362 | |
| BMI | |||||
| ≥24 vs. <24 kg/m2 | 1.378 (0.866–2.192) | 0.176 | 1.438 (0.867–2.387) | 0.159 | |
| Primary tumor gradea | |||||
| G3 vs. G1–2 | 1.136 (0.680–1.900) | 0.626 | 1.149 (0.672–1.965) | 0.612 | |
| Primary tumor location | |||||
| Right-sided vs. left-sided | 1.378 (0.783–2.425) | 0.266 | 1.153 (0.627–2.119) | 0.647 | |
| T-stagea | |||||
| pT4 vs. pT1–3 | 1.466 (0.936–2.295) | 0.094 | 1.441 (0.878–2.364) | 0.148 | |
| N-stagea | |||||
| pN1–2 vs. pN0 | 1.749 (1.073–2.850) | 0.025b | 1.452 (0.867–2.434) | 0.157 | |
| Synchronous metastases | |||||
| Present vs. absent | 0.930 (0.500–1.731) | 0.820 | 0.577 (0.281–1.186) | 0.135 | |
| Resection status | |||||
| Heterochronous vs. synchronous | 1.803 (1.144–2.840) | 0.011b | 1.850 (1.081–3.165) | 0.025b | |
| Preoperative chemotherapy before primary tumor resection | |||||
| Yes vs. no | 1.525 (0.965–2.410) | 0.071 | 1.528 (0.902–2.587) | 0.115 | |
| Immune score LM | |||||
| High vs. low | 0.617 (0.385–0.989) | 0.045b | 0.677 (0.409–1.120) | 0.129 | |
| Immune score PT | |||||
| High vs. low | 1.115 (0.707–1.759) | 0.640 | 0.986 (0.577–1.684) | 0.958 | |
a, according to Union for International Cancer Control (UICC) staging system (7th edition); b, P value <0.05 was defined as statistically significant. BMI, body mass index; LM, liver metastases; PT, primary tumor.