. 2021 Feb;9(4):310. doi: 10.21037/atm-20-4932

Table 4. Predictive factors for overall survival by univariate and multivariate analysis in all patients.

Characteristics	Univariate analysis		Multivariate analysis
Characteristics	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
Age
>65 vs. ≤65 years	1.154 (0.573–2.324)	0.688	1.440 (0.656–3.159)	0.363
Gender
Male vs. female	0.990 (0.552–1.775)	0.974	0.810 (0.441–1.487)	0.496
BMI
≥24 vs. <24 kg/m²	1.809 (1.002–3.266)	0.049^b	1.694 (0.876–3.276)	0.117
Primary tumor grade^a
G3 vs. G1–2	2.301 (1.235–4.286)	0.009^b	2.419 (1.249–4.683)	0.009^b
Primary tumor location
Right-sided vs. left-sided	1.412 (0.660–3.024)	0.374	1.113 (0.466–2.658)	0.810
T-stage^a
pT4 vs. pT1–3	1.301 (0.735–2.302)	0.367	1.564 (0.807–3.035)	0.185
N-stage^a
pN1–2 vs. pN0	1.695 (0.913–3.145)	0.095	1.087 (0.545–2.169)	0.812
Synchronous metastases
Present vs. absent	1.388 (0.704–2.736)	0.343	0.738 (0.321–1.697)	0.475
Resection status
Heterochronous vs. synchronous	1.687 (0.931–3.057)	0.085	1.961 (0.939–4.094)	0.073
Preoperative chemotherapy before primary tumor resection
Yes vs. no	1.577 (0.871–2.854)	0.133	2.146 (1.047–4.399)	0.037^b
Immune score LM
High vs. low	0.405 (0.222–0.737)	0.003^b	0.507 (0.261–0.983)	0.044^b
Immune score PT
High vs. low	0.802 (0.443–1.452)	0.465	0.636 (0.314–1.288)	0.209

^a, according to Union for International Cancer Control (UICC) staging system (7th edition); ^b, P value <0.05 was defined as statistically significant. BMI, body mass index; LM, liver metastases; PT, primary tumor.