Table 5. Predictive factors for relapse-free survival by univariate and multivariate analysis in patients underwent heterochronous resection.
| Characteristics | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| Age | |||||
| >65 vs. ≤65 years | 0.316 (0.096–1.041) | 0.058 | 0.478 (0.116–1.964) | 0.306 | |
| Gender | |||||
| Male vs. female | 0.763 (0.413–1.408) | 0.387 | 0.591 (0.272–1.287) | 0.185 | |
| BMI | |||||
| ≥24 vs. <24 kg/m2 | 1.257 (0.689–2.294) | 0.455 | 1.982 (0.967–4.063) | 0.062 | |
| Primary tumor gradea | |||||
| G3 vs. G1–2 | 1.390 (0.682–2.832) | 0.365 | 1.692 (0.669–4.281) | 0.267 | |
| Primary tumor location | |||||
| Right-sided vs. left-sided | 1.045 (0.371–2.941) | 0.934 | 1.351 (0.452–4.035) | 0.590 | |
| T-stagea | |||||
| pT4 vs. pT1–3 | 1.430 (0.777–2.631) | 0.250 | 1.299 (0.609–2.770) | 0.498 | |
| N-stagea | |||||
| pN1–2 vs. pN0 | 1.164 (0.621–2.182) | 0.635 | 0.831 (0.390–1.770) | 0.632 | |
| Preoperative chemotherapy before primary tumor resection | |||||
| Yes vs. no | 1.227 (0.668–2.257) | 0.510 | 1.380 (0.564–3.377) | 0.481 | |
| Preoperative chemotherapy before liver resection | |||||
| Yes vs. no | 3.074 (1.442–6.555) | 0.004b | 3.479 (1.421–8.518) | 0.006b | |
| Immune score LM | |||||
| High vs. low | 0.577 (0.308–1.081) | 0.086 | 0.429 (0.208–0.882) | 0.021b | |
| Immune score PT | |||||
| High vs. low | 1.076 (0.590–1.964) | 0.811 | 1.536 (0.618–3.819) | 0.355 | |
a, according to Union for International Cancer Control (UICC) staging system (7th edition); b, P value <0.05 was defined as statistically significant. BMI, body mass index; LM, liver metastases; PT, primary tumor.