. 2021 Feb;9(4):310. doi: 10.21037/atm-20-4932

Table 6. Predictive factors for overall survival by univariate and multivariate analysis in patients underwent heterochronous resection.

Characteristics	Univariate analysis		Multivariate analysis
Characteristics	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
Age
>65 vs. ≤65 years	0.357 (0.083–1.536)	0.166	1.121 (0.200–6.285)	0.896
Gender
Male vs. female	0.738 (0.345–1.580)	0.435	0.808 (0.309–2.116)	0.664
BMI
≥24 vs. <24 kg/m²	1.655 (0.782–3.502)	0.188	2.656 (1.066–6.618)	0.036^b
Primary tumor grade^a
G3 vs. G1–2	2.321 (1.010–5.332)	0.047^b	5.400 (1.675–17.414)	0.005^b
Primary tumor location
Right-sided vs. left-sided	1.388 (0.324–5.940)	0.658	1.614 (0.359–7.255)	0.532
T-stage^a
pT4 vs. pT1–3	1.304 (0.612–2.777)	0.491	1.440 (0.537–3.862)	0.468
N-stage^a
pN1–2 vs. pN0	1.273 (0.588–2.755)	0.540	0.553 (0.195–1.567)	0.265
Preoperative chemotherapy before liver resection
Yes vs. no	1.289 (0.614–2.703)	0.502	4.167 (1.362–12.743)	0.012^b
Preoperative chemotherapy before liver resection
Yes vs. no	1.646 (0.717–3.779)	0.240	3.280 (1.088–9.886)	0.035^b
Immune score LM
High vs. low	0.438 (0.200–0.959)	0.039^b	0.340 (0.130–0.889)	0.028^b
Immune score PT
High vs. low	0.766 (0.360–1.628)	0.488	0.502 (0.157–1.600)	0.244

^a, according to Union for International Cancer Control (UICC) staging system (7th edition); ^b, P value <0.05 was defined as statistically significant. BMI, body mass index; LM, liver metastases; PT, primary tumor.