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. 2021 Feb;9(4):349. doi: 10.21037/atm-21-367

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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The trends between fALFF and age within the right precuneus, left PCC, MCC, left AG, and right SMG for the MDD and HC groups. The red points and line represent the fALFF value and the fitting curve, respectively, for MDD; the blue points and line represent the fALFF values and the fitting curve, respectively, for HC. HC exhibited significant quadratic age effects. fALFF, fractional amplitude of low frequency ﬂuctuations; MCC, middle cingulate cortex; PCC, posterior cingulate cortex; AG, angular gyrus; SMG, supramarginal gyrus; MDD, major depressive disorder; HC, healthy controls.