Table 4. Regions with increased and decreased fALFF in patients with MDD relative to HC.

fALFF	Anatomical	Hemisphere	BA	Cluster voxels	MNI (x, y, z)	T
Adolescents
Increased	Medial superior frontal gyrus	R	9	28	3, 45, 45	4.44
	Medial superior frontal gyrus	L	6	20	0, 44, 42	4.11
Decreased	Pallidum	R	48	49	27, 15, −6	−4.54
Young adults
Increased	Parahippocampal gyrus	L	35	25	−21, −3, −36	4.48
	Cerebelum_9	R	0	59	6, −54, −30	5.58
	Cerebelum_9	L	0	51	−6, −46, −42	3.88
	Middle temporal pole	R	36	20	27, 6, −39	4.24
	Middle temporal gyrus	L	20	32	−48, −18, −15	4.80
	Hippocampus	R	20	25	27, −12, −18	4.39
	Caudate	L	25	21	−6, 15, 3	4.07
Decreased	The orbital part of middle frontal gyrus	R	47	49	36, 51, −12	−4.64
	Superior frontal gyrus	R	10	30	24, 63, 6	−3.48
	The orbital part of medial frontal gyrus	L	11	20	−6, 63, −12	−3.60
	Superior temporal gyrus	R	42	25	51, −39, 15	−4.39
	Middle frontal gyrus	R	45	126	36, 39, 18	−5.14
	The triangular part of inferior frontal gyrus	R	48	69	51, 22, 15	−3.64
	The opercular part of inferior frontal gyrus	R	47	37	39, 46, −12	−3.74
	Postcentral gyrus	R	4	37	51, −3, 27	−4.57
	Supramarginal gyrus	R	2	127	54, −36, 36	−5.94
	Inferior parietal gyrus	R	40	81	42, −43, 45	−4.01
	Angular gyrus	R	39	26	51, −51, 35	−4.12
Middle-aged adults
Increased	Middle frontal gyrus	R	9	136	48, 19, 46	4.44
	Middle frontal gyrus	L	8	136	−27, 21, 60	4.77
	Superior frontal gyrus	R	8	78	15, 30, 60	4.22
	Superior frontal gyrus	L	46	51	−24, 60, 27	4.29
	Precentral gyrus	L	6	76	−36, −7, 64	4.00
Decreased	Calcarine	L	17	67	−3, −72, 15	−4.47
	Calcarine	R	17	114	12, −64, 12	−3.91
	Cuneus	R	18	56	3, −78, 24	−4.20
	Cuneus	L	18	42	0, −75, 24	−4.34
	Precuneus	L	7	33	−3, −70, 39	−3.93
	Precuneus	R	7	29	3, −73, 39	−4.40
Old adults
Increased	Inferior temporal gyrus	L	37	11	−51, −63, −12	4.69
Decreased	Middle cingulate gyrus	L	23	11	−3, −12, 39	−4.54

BA, Brodmann area; fALFF, fractional amplitude of low frequency fluctuations; MDD, major depressive disorder; HC, healthy controls.