Table 2. Adjusting for different clinicopathological features in univariate and multivariate Cox regression analysis.

Variables	Univariate Cox regression				Multivariate Cox regression
	HR	Confidence interval	P		HR	Confidence interval	P
Age	1.034	1.020–1.049	<0.001*		1.035	1.020–1.050	<0.001*
Stage	2.114	1.673–2.672	<0.001*		1.372	0.810–2.324	0.240
T	1.574	1.269–1.954	<0.001*		1.008	0.744–1.365	0.960
M	6.005	3.302–10.922	<0.001*		2.126	0.921–4.907	0.077
N	1.671	1.393–2.003	<0.001*		1.214	0.893–1.649	0.216
Risk score	4.698	3.362–6.567	<0.001*		4.425	3.116–6.284	<0.001*

*P<0.05 was considered statistically significant. HR, hazard ratio; T, tumor; N, node (lymph node); M, metastasis.