Table 3.
Linear regression analyses of galectin‐3 binding protein‐expressing microvesicles by clinical and serological features of SLE
| Independent variables | Coefficients (B) | 95% CI | P‐values | |
|---|---|---|---|---|
| G3BP‐expressing MVs in % of total MV count | ||||
| LN (active) | 19·3 | 4·5 to 34·2 | 0·02 | Model 1 |
| SLEDAI score | 0·4 | −0·1 to 1·8 | 0·53 | Model 2 |
| SLEDAI score (excluding LN) | 0·02 | −1·6 to 1·7 | 0·98 | Model 3 |
| Anti‐dsDNA antibodies (titer) a | 0·05 | −0·01 to 0·12 | 0·11 | Model 4 |
| MFI of G3BP‐expressing MVs | ||||
| LN (active) | 69·3 | 16·6 to 122 | 0·02 | Model 1 |
| SLEDAI score | 2·4 | −2·4 to 7·2 | 0·3 | Model 2 |
| SLEDAI score (excluding LN) | 1·3 | −4·5 to 7·2 | 0·62 | Model 3 |
| Anti‐dsDNA antibodies (titer) a | 0·2 | 0·01 to 0·41 | 0·04 | Model 4 |
Simple linear regressions were performed for SLE patients (n = 12), with (a) proportions of G3BP‐expressing MVs in toto and (b) the corresponding G3BP MFIs as dependent variables (after ODN2395‐stimulation), and with LN, SLEDAI scores and anti‐dsDNA antibody titers as independent variables (models 1–4). Model 3 in both (a) and (b) depicts the regression coefficients and P‐values for SLEDAI scores when excluding renal manifestations from the index (i.e. subtracting four points for each patient with active LN). Significant P‐values are marked in bold type.
SLE = systemic lupus erythematosus; MV = microvesicle; G3BP = galectin‐3 binding protein; MFI = median fluorescence intensity; ODN = oligodeoxynucleotide; LN = lupus nephritis; SLEDAI = Systemic Lupus Erythematosus Disease Activity Index.
n = 10 (five with active LN).