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. 2021 Mar 5;16:1869–1888. doi: 10.2147/IJN.S289733

Figure 7.

Figure 7

In vivo antineoplastic effect of T22-AUR in a disseminated mouse model of CXCR4+ DLBCL-Luci cells. (A) Representative images of lymphoma dissemination, registered by measuring the BLI emitted by U-2932-Luci cells, in animals treated with buffer or T22-AUR at the last days of the experiment (days 23 and 30 postinjection of lymphoma cells). (B) Area under the curve (AUC) of the lymphoma follow-up (from day 1 to day 30) registered by total BLI emission from buffer-treated mice (n=9) and T22-AUR-treated mice (n=10). (C) Body weight of mice treated with buffer (n=9) or T22-AUR (n=10) during the whole experiment. (D) Quantification of the total BLI registered (above) and representative images (below) from CNS and BM in buffer (n=9) and T22-AUR-treated mice (n=10). All data are shown as mean ± standard error. *p≤0.05; **p≤0.01.

Abbreviations: BLI, bioluminescence imaging; BM, bone marrow; CNS, central nervous system.