. 2020 Dec 22;95(2):e00730-20. doi: 10.1128/JVI.00730-20

TABLE 2.

Conservation of amino acids of 16 E6 important for p53 binding (17)^a

HPV type	Conserved amino acid
16 E6	Q6	E7	R8	Q14	E18^b	Y43	D44^b	F47^b	D49^b	L100	P112
31 E6	A6	E7	R8	E14	A18	L43	D44^b	F47^b	D49^b	L100	P112

Variations between 16 E6 and 31 E6 are highlighted in bold.

Mutations show a significant decrease in binding.