TABLE 1.
Infection rate by challenge dose
| Macaque | Detection of SHIV.C.CH505 in animals challenged with the indicated inocula (ng of p27)a |
||||
|---|---|---|---|---|---|
| 45/45, 2/4 macaques (50%) |
90/90, 6/8 macaques (75%) |
180/180, 2/5 macaques (40%) |
360/360,b 4/6 macaques (66%) |
360/360,c 2/2 macaques (100%) |
|
| RWc19 | + | ||||
| RDd19 | + | ||||
| RLd19 | – | – | – | + | |
| RQc19 | – | + | |||
| RAf19 | + | ||||
| RCg19 | + | ||||
| RKg19 | + | ||||
| RLg19 | + | ||||
| RVh19 | + | ||||
| RTi19 | – | – | + (180/360) | ||
| RJm19 | + | ||||
| RRm19 | + | ||||
| RIm19 | – | + (180/360) | |||
| RTp19 | + (180/360) | ||||
| RVr19 | – | + | |||
| RGs19 | – | + | |||
a
+, detectable viral loads by 7 days p.i.; –, undetectable viral loads by 7 days p.i.
b
Numbers in parentheses are modified doses.
c
For animals rechallenged with 360 ng p27, the dose was not escalated.