Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
In PARAMAOUNT trial11 performed in heart failure with preserved ejection fraction subjects, sacubitril–valsartan administration was followed by reduction of NT pro-BNP after 4 weeks treatment that became statistically significant after 12 week of therapy and was sustained to 36 weeks, though the between group difference was no longer significant because valsartan treated group displayed a delayed NT-proBNP decline.
