Table 3.

Association between diagnostic delay and development of stricturing and/or internal fistulising complications among CD patients with inflammatory disease at presentation.

Factors	Unadjusted hazard ratioa [95% CI]	p-value	Adjusted hazard ratio [95% CI]	p-value
Diagnostic delayb	2.53 [1.41–4.56]	0.002	2.28 [1.25–4.14]	0.007
Male	0.59 [0.33–1.06]	0.087	0.58 [0.32–1.06]	0.077
Age at diagnosis [years]	1.11 [0.99–1.24]	0.076	1.07 [0.94–1.20]	0.29
Small bowel involvementc	4.45 [1.59–12.5]	0.004	4.07 [1.44–11.5]	0.008
Upfront anti-TNF used	0.26 [0.06–1.10]	0.067	0.30 [0.07–1.25]	0.098

CD, Crohn’s disease; HR, hazard ratio; CI, confidence interval; TNF, tumour necrosis factor.

^aHR >1 indicates faster time to diagnosis; HR <1 indicates slower time to diagnosis.

^bTime to diagnosis >75th percentile in CD subgroup [10.8 months].

^cL1, L3 or L4b.

^dAs first therapy.