Table 5.

Association between diagnostic delay and surgery in CD patients.

Factors	Unadjusted hazard ratio [95% CI]a	p-value	Adjusted hazard ratio [95% CI]	p-value
Diagnostic delayb	1.01 [0.60–1.70]	0.97	0.93 [0.55–1.59]	0.80
Male	0.92 [0.59–1.46]	0.74	0.90 [0.57–1.44]	0.67
Age at diagnosis [years]	1.04 [0.96–1.12]	0.38	1.02 [0.94–1.11]	0.55
Distal ileal ± caecal [L1]	1.74 [1.05–2.88]	0.032	1.71 [1.03–2.86]	0.040
Upfront anti-TNF use2	1.35 [0.77–2.38]	0.30	1.37 [0.77–2.42]	0.28

CD, Crohn’s disease; TNF, tumour necrosis factor; CI, confidence nterval; HR, hazard ratio.

^aHR >1 indicates faster time to diagnosis; HR <1 indicates slower time to diagnosis.

^bTime to diagnosis >75th percentile in CD subgroup [10.8 months].

^cAs first therapy.