Table 6.

Association between diagnostic delay and surgery in UC/IBD-U patients.

Factorsa	Unadjusted hazard ratio [95% CI]c	p-value	Adjusted hazard ratio [95% CI]	p-value
Diagnostic delayb	0.35 [0.11–1.16]	0.085	0.41 [0.12–1.34]	0.14
Male	1.70 [0.81–3.55]	0.16	1.70 [0.81–3.55]	0.16
Age at diagnosis [years]	1.01 [0.91–1.12]	0.85	1.02 [0.92–1.12]	0.78
Pancolitis [E4]	2.26 [0.87–5.90]	0.094	2.14 [0.82–5.58]	0.12

UC/IBDU, ulcerative colitis/inflammatory boweldisease unclassified; TNF, tumour necrosis factor; CI, confidence nterval; HR, hazard ratio.

^aAnti-tumour necrosis factor-alpha [anti-TNF] use not included in model as virtually all UC/IBD-U patients who underwent surgery were first treated with anti-TNF [positioning anti-TNF use in the causal pathway].

^bTime to diagnosis >75th percentile in UC/IBD-U subgroup [6.6 months].

^cHR >1 indicates faster time to diagnosis; HR <1 indicates slower time to diagnosis.