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. 2021 Mar 7;49(3):0300060521994926. doi: 10.1177/0300060521994926

Table 1.

Main characteristics of studies included in the meta-analysis.

Study cohort Year Study region Ethnicity Patients/controls Age, years (median, range) Cancer type Control group TNM Cut-off Method Sensitivity Specificity
Duan et al. 21 2020 China Asian 34/20 59 (30–81) NSCLC Healthy I 1 FISH 43.18 100
He et al.25 2020 China Asian 24/72 59.4 (25–85) NSCLC Healthy I–II 1 FISH 62.5 100
Li et al.27 2019 China Asian 174/90 58.5 LC Healthy/BLD I–IV 2/3.2 mL FISH 68.39 100
Gu et al.24 2020 China Asian 140/140 65.5 NSCLC Healthy I–II NR FISH 67.1 80
Zhang et al.33 2019 China Asian 91/20 69±5.9 LC Healthy/BLD III–IV 1 FISH 61.5 100
Manjunath et al.13 2019 America Caucasian 29/20 56.55±12.04 NSCLC Healthy I–IV 21 FISH 41.4 100
Zhou et al.35 QJ1 2019 China Asian 197/63 64.26 (36–84) LC BLD I–IV 8.3 U/3 mL PCR 78.6 78.4
Zhou et al.35 QJ2 2019 China Asian 93/29 61.4 LC BLD I–IV 8.3 U/3 mL PCR 82.7 68.8
Qian et al.28 2018 China Asian 200/50 NR LC Healthy I–IV 3.5/mL FISH 86 98
Chen et al.17 2018 China Asian 41/10 59.34±11.72 NSCLC Healthy NR 1/2 ml PCR 0.732 100
Gao et al.23 2018 China Asian 143/42 N LC Healthy I–IV 2.25/mL PCR 72 97.6
Ye et al.31 2019 China Asian 85/30 61 (44–71) LC Healthy NR 1/7.5 ml FISH 92.9 100
Xue et al.30 2018 China Asian 72/26 56 (32–77) NSCLC Healthy/BLD I–IV 8.7 U/3 mL PCR 81.94 73.08
Zhong et al.34 2018 China Asian 241/61 NR LC BLD I–IV 1.5 FISH 90.5 86.9
Fiorelli et al.22 2015 Italy Caucasian 60/17 62.3 (32–87) NSCLC BLD I–IV 25 IHC 89 100
Chen et al.18 X1 2015 China Asian 236/141 71 (48–91) NSCLC Healthy/BLD I–IV 8.93 U/3 mL PCR 72.46 88.65
Chen et al.18 X2 2015 China Asian 237/142 58 NSCLC Healthy/BLD I–IV 8.93 U/3 mL PCR 76.37 82.39
Chen et al.19 2014 China Asian 50/42 63 (33–82) LC Healthy/BLD I–III 2/3.2 mL FISH 84 97.6
Yu et al.32 2013 China Asian 153/113 60 (21–81) NSCLC Healthy/BLD I–IV 8.64 U PCR 73.2 84.1
Lou et al.16 2013 China Asian 33/44 57 (27–79) NSCLC Healthy/BLD I–III 8.5 U PCR 81.8 93.2
Devriese et al.20 2012 America Caucasian 46/46 59 (33–82) NSCLC Healthy IIIb–IV 1 PCR 46 93
Hofman et al.26 2011 France Caucasian 210/40 59 (23–83) NSCLC Healthy I–IV 2 IHC 39 100
Tanaka et al.29 2009 Japan Asian 125/25 61 (43–88) LC BLD I–IV 1 FISH 30.4 88

BLD, benign lung disease; NR, not reported; NSCLC, non-small cell lung cancer; LC lung cancer; IHC, immunohistochemistry; FISH, fluorescence in situ hybridization; PCR, polymerase chain reaction.