Table 2.
Subgroup analyses.
| Variable | Sensitivity (95% CI) | I | Specificity (95% CI) | I | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) |
|---|---|---|---|---|---|---|---|
| Subgroup analyses | |||||||
| Subgroup 1 | |||||||
| Asian | 0.75 (0.68–0.81) | 92.52 | 0.94 (0.88–0.97) | 81.26 | 13.49 (6.27–29.01) | 0.26 (0.20–0.34) | 51.17 (21.81–120.07) |
| Caucasian | 0.56 (0.32–0.77) | 94.42 | 0.99 (0.67–1.00) | 64.67 | 58.66 (1.10–3119.96) | 0.45 (0.25–0.78) | 131 (2.00–8708.18) |
| Subgroup 2 | |||||||
| Sample size ≥100 | 0.73 (0.63–0.81) | 96.05 | 0.94 (0.86–0.97) | 81.10 | 11.42 (5.00–26.07) | 0.29 (0.21–0.40) | 39.99 (15.51–103.09) |
| Sample size <100 | 0.70 (0.58–0.81) | 84.66 | 0.98 (0.90–1.00) | 81.19 | 34.13 (6.88–169.37) | 0.30 (0.21–0.44) | 113.25 (22.00–583.08) |
| Subgroup 3 | |||||||
| NSCLC | 0.68 (0.57–0.77) | 93.10 | 0.95 (0.86–0.98) | 79.22 | 13.34 (4.71–37.75) | 0.34 (0.26–0.46) | 38.98 (13.62–111.56) |
| Lung cancer | 0.76 (0.65–0.84) | 95.15 | 0.96 (0.88–0.99) | 83.36 | 18.83 (6.23–56.91) | 0.25 (0.17–0.37) | 74.29 (21.54–256.19) |
| Subgroup 4 | |||||||
| Healthy | 0.66 (0.53–0.73) | 94.42 | 0.99 (0.93–1.00) | 87.52 | 60.39 (9.46–385.37) | 0.34 (0.23–0.50) | 177 (25.17–1246.67) |
| Healthy/benign lung disease | 0.73 (0.69–0.77) | 58.11 | 0.94 (0.83–0.98) | 78.49 | 11.41 (4.08–31.90) | 0.29 (0.26–0.32) | 39.76 (14.17–111.60) |
| Benign lung disease | 0.78 (0.57–0.91) | 97.90 | 0.84 (0.74–0.91) | 61.99 | 4.83 (2.77–8.44) | 0.26 (0.12–0.57) | 18.42 (5.75–59.00) |
| Subgroup 5 | |||||||
| Early stage | 0.70 (0.59–0.80) | 77.36 | 0.98 (0.83–1.00) | 88.72 | 29.32 (3.74–229.90) | 0.30 (0.21–0.43) | 96.62 (12.01–777.58) |
| Late stage | 0.56 (0.48–0.65) | 68.00 | 0.96 (0.87–0.99) | 55.10 | 8.48 (2.96–24.27) | 0.48 (0.32–0.71) | 18.29 (3.97–84.46) |
| I–IV | 0.73 (0.63–0.81) | 95.99 | 0.93 (0.85–0.97) | 79.37 | 10.84 (4.91–23.95) | 0.29 (0.21–0.41) | 37.11 (15.75–87–46) |
| Subgroup 6 | |||||||
| PCR | 0.74 (0.69–0.79) | 70.13 | 0.86 (0.80–0.91) | 65.39 | 5.47 (3.82–7.82) | 0.30 (0.26–0.34) | 18.34 (13.16–25.59) |
| FISH | 0.71 (0.57–0.82) | 95.48 | 0.99 (0.93–1.00) | 86.92 | 52.90 (9.07–308.72) | 0.30 (0.19–0.46) | 179.29 (27.60–1166.02) |
CI, confidence interval; DOR, diagnostic odds ratio; FISH, fluorescence in situ hybridization; NLR, negative likelihood ratio; NSCLC, non-small cell lung cancer; PCR, polymerase chain reaction; PLR, positive likelihood ratio.