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A schematic representation of a model for the role of Shp2 in the regulation of sEV biogenesis. [Shp2 decreases the tyrosine phosphorylation of Syntenin. Shp2 depletion increased Syntenin‐mediated sEV formation, thus promoting sEVs transferring from epithelial cells to macrophages. As a result, increased epithelial sEVs induced macrophages activation]
