Table 1. Up- and Down-Regulated Proteins in Expression between APP/PS1 and WT.
| protein Id | gene symbol | WT average | APP/PS1 average | fold change | –log10(p-value)a |
|---|---|---|---|---|---|
| E9Q2W9 | Actn4 | 34.11 | 20.29 | 0.59 | 1.562 |
| Q9ERF3 | Wdr61 | 32.77 | 20.62 | 0.63 | 2.349 |
| Q9EST5 | Anp32b | 47.50 | 23.84 | 0.50 | 1.812 |
| Q9DC61 | Pmpca | 28.57 | 11.91 | 0.42 | 2.019 |
| Q9JIZ0 | Cml1 | 45.26 | 33.66 | 0.74 | 1.311 |
| P46735 | Myo1b | 181.70 | 146.27 | 0.81 | 2.917 |
| E9Q137 | Tex264 | 167.37 | 123.23 | 0.74 | 1.527 |
| Q62148 | Aldh1a2 | 237.12 | 148.74 | 0.63 | 1.996 |
| Q9D6J6 | Ndufv2 | 575.30 | 330.89 | 0.58 | 1.413 |
| Q8C5H8 | Nadk2 | 153.93 | 131.47 | 0.85 | 1.324 |
| P16254 | Srp14 | 159.83 | 111.25 | 0.70 | 1.794 |
| O35887 | Calu | 596.76 | 394.05 | 0.66 | 1.892 |
| P24472 | Gsta4 | 260.99 | 200.33 | 0.77 | 1.753 |
| Q9CQN1 | Trap1 | 131.26 | 98.76 | 0.75 | 1.512 |
| Q05920 | Pc | 944.43 | 818.06 | 0.87 | 1.658 |
| Q8BIP0 | Dars2 | 27.08 | 18.13 | 0.67 | 1.895 |
| Q6ZQK5 | Acap2 | 811.17 | 944.92 | 1.16 | 1.452 |
| P62242 | Rps8 | 647.87 | 897.33 | 1.39 | 1.536 |
| P62301 | Rps13 | 600.46 | 848.51 | 1.41 | 1.364 |
| Q8BT60 | Cpne3 | 1068.06 | 1156.14 | 1.08 | 1.351 |
| P39447 | Tjp1 | 124.75 | 156.82 | 1.26 | 1.990 |
| Q61730 | Il1rap | 1109.54 | 1283.78 | 1.16 | 1.371 |
| P48036 | ANXA5 | 2756.53 | 3220.07 | 1.17 | 1.693 |
| Q921E2 | Rab31 | 93.36 | 121.57 | 1.30 | 1.387 |
| P14824 | Anxa6 | 3667.05 | 4291.27 | 1.17 | 1.467 |
| P58021 | Tm9sf2 | 321.28 | 416.33 | 1.30 | 1.364 |
| P05067-4 | APP | 1441.70 | 3198.42 | 2.22 | 2.850 |
| P49768 | PSEN1 | 229.33 | 382.95 | 1.67 | 4.245 |
| Q91VU0 | Fam3c | 103.78 | 141.34 | 1.36 | 1.439 |
| Q99PD7 | Slc24a3 | 59.07 | 79.27 | 1.34 | 1.524 |
| Q9CQJ6 | Denr | 26.78 | 36.86 | 1.38 | 1.710 |
| Q9JJC6 | Rilpl1 | 22.97 | 30.63 | 1.33 | 1.476 |
| Q80TL7 | Mon2 | 103.59 | 129.03 | 1.25 | 1.681 |
| Q3B7Z2 | Osbp | 370.13 | 474.24 | 1.28 | 1.308 |
| Q9QXH4 | Itgax | 29.00 | 78.77 | 2.72 | 2.291 |
| Q8C7N7 | Aph1b | 69.45 | 102.88 | 1.48 | 1.993 |
| P06800 | Ptprc | 143.06 | 210.96 | 1.47 | 1.636 |
| P20491 | Fcer1g | 86.16 | 127.79 | 1.48 | 1.455 |
| Q9CPV9 | P2ry12 | 2248.44 | 2808.41 | 1.25 | 1.613 |
| P60766 | Cdc42 | 844.66 | 932.37 | 1.10 | 0.370 |
| Q80UP3 | Dgkz | 167.80 | 207.27 | 1.24 | 1.670 |
| P62192 | Psmc1 | 1531.69 | 1674.17 | 1.09 | 1.746 |
| Q5SYD0 | Myo1d | 1717.22 | 2076.67 | 1.21 | 1.350 |
| A2ADY9 | Ddi2 | 84.14 | 104.29 | 1.24 | 2.941 |
| A2AF47 | Dock11 | 198.13 | 296.61 | 1.50 | 1.329 |
| Q8BIK4-2 | Dock9 | 725.87 | 1049.00 | 1.45 | 1.415 |
a
The t-test was calculated by Welch’s test.