FIGURE 2.

A low dose of cilengitide increased VEGF-A expression in ischemic muscles. (A)The levels of VEGF-A mRNA expression were measured by quantitative RT-PCR in nonischemic and ischemic muscle at 14 days after surgery. The results are shown as the mean ± SEM (n = 6 per group). *p < 0.05 vs. vehicle and cilengitide (5 mg/kg). (B) VEGF-A expression levels detected by ELISA in gastrocnemius muscles from 14 days after surgery. The ratio of protein in the ischemic to the nonischemic muscle was calculated for each mouse. The results are shown as the mean ± SEM (n = 6 per group). *p < 0.05 vs. vehicle and cilengitide (5 mg/kg).