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. Author manuscript; available in PMC: 2021 Mar 10.
Published in final edited form as: Mol Pharm. 2019 Dec 16;17(1):98–108. doi: 10.1021/acs.molpharmaceut.9b00788

Table 1.

Click Therapy Treatment Schedule

Treat group Pretargeting comp. (20 μg/mL, 130/180 nM) Drug delivery comp. (50 μg/mL, 600 nM)
  1     5D3(TCO)8  ALB(DM1)3.3(PEG4-Tz)10
  2     F(ab′)2(TCO)8  ALB(DM1)3.3(PEG4-Tz)10
  3     5D3  ALB(DM1)3.3(PEG4-Tz)10
  4     F(ab′)2  ALB(DM1)3.3(PEG4-Tz)10
  5     5D3(TCO)8
  6     F(ab′)2(TCO)8
  7     5D3
  8     F(ab′)2
  9  DM1 (2 μM)a
  10  ALB(DM1)3.3(PEG4-Tz)10
a

The concentration of pure DM1 was equivalent for DM1 content in a drug delivery component.