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. 2021 Mar 10;16:16. doi: 10.1186/s13024-021-00437-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — High dose of AAV-HMOX1 causes photoreceptor degeneration. a Immunostaining of Recoverin (panels a') and GFAP (panels b') in the retinas from albino mice 2 weeks after infection with a low or a high dose of AAV8-HMOX1 virus. b, c Cell death analysis by TUNEL assay in retinas from albino mice under the indicated conditions b and the quantification of the TUNEL-positive cells in the photoreceptor cell layer of the mice c (Error bars: SD; n = 3, Student T-test). AAV-HMOX1 L, low dose of AAV-HMOX1; AAV-HMOX1 H, high dose of AAV-HMOX1; GCL:ganglion cell layer; INL:inner nuclear layer; ONL: outer nuclear layer; IS: photoreceptor inner segments; OS: photoreceptor outer segments; ns, no significant difference; *** indicates p < 0.001. Scale bars: 50 μm