Fig. 8.

Deletion of Ddit3 prevents photoreceptor degeneration caused by the excessive HMOX1 levels. a, b Histological images of H&E staining from Ddit3+/+(n = 3) and Ddit3−/− mice (n = 3) 2 weeks after infection with a high dose of AAV8-GPF or AAV8-HMOX1 (a) and curve diagram of PL thickness according to the H&E staining (b) (Error bars: SD; one-way ANOVA; *, p < 0.05; **, p < 0.01; ***, p < 0.001;). c, d Immunostaining images of anti-GFAP or anti rhodopsin in retinas from Ddit3+/+ (n = 3) and Ddit3−/− (n = 3) mice under the indicated conditions. GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; PL, photoreceptor layer; ns, no significant difference. * or ** or *** indicates p < 0.05 or p < 0.01 or p < 0.001. Scale bars: 50 μm