Table 2.
Benchtop, short-term, long-term, and freeze/thaw stability of remdesivir.
| Matrix, Conditions | Nominal (ng/mL) | GM (ng/mL) | SD (ng/mL) | CV (%) | DEV from Fresh (%) | n |
|---|---|---|---|---|---|---|
| Plasma, RT, 4 h | 10 | 9.73 | 0.364 | 3.74 | −4.04 | 4 |
| 2000 | 1770 | 40.1 | 2.27 | −5.47 | 4 | |
| DMSO, RT, 4 h | 10 | 9.38 | 0.190 | 2.02 | −7.44 | 4 |
| 2000 | 1860 | 56.0 | 3.01 | −0.53 | 4 | |
| DMSO (−80 °C, 15 days) | 10 | 9.79 | 0.571 | 5.83 | 11.6 | 6 |
| 2000 | 1.90 × 103 | 115 | 6.02 | 1.63 | 6 | |
| DMSO (−80 °C, 5 months) | 10 | 10.9 | 0.400 | 3.67 | 9.00 | 4 |
| 2000 | 1930 | 54.4 | 2.82 | −3.90 | 4 | |
| Freeze/thaw (4 cycles) | 1.5 | 1.60 | – | – | 3.90 | 5 |
| 4000 | 3.80 × 103 | 85.0 | 2.24 | −9.61 | 5 |
Abbreviations: RT, room temperature; GM, grand mean; SD, standard deviation; CV (%), coefficient of variation; DEV from Fresh (%) relative deviation from GM of freshly prepared samples; n, total number of samples. A dash (-) indicates no observed SD/CV.