Table 1.
Number of immune-related gene family members from sequenced Dipteran genomes, annotated by hidden Markov models
| Scal | Mdom | Gmor | Aaeg | Dmel | |
|---|---|---|---|---|---|
| Canonical pattern recognition | |||||
| Nimorod (NIM) | 25 | 23 | 10 | 8 | 17 |
| Peptidoglycan recognition protein (PGRP) | 17 | 17 | 4 | 10 | 13 |
| beta-1,3-glucan-binding proteins (BGBP) | 4 | 3 | 3 | 7 | 7 |
| Thioester containing proteins (TEP) | 16 | 22 | 4 | 8 | 6 |
| Other recognition | |||||
| C-type lectin (CTL) | 78 | 41 | 11 | 43 | 38 |
| Fibrinogen-related proteins (FREP) | 49 | 38 | 7 | 34 | 14 |
| Galectins (GALE) | 15 | 13 | 8 | 12 | 6 |
| Immunoglobulin superfamily (IGSF) | 1 | 1 | 1 | 0 | 1 |
| MD2-like proteins (MD2L) | 8 | 12 | 5 | 26 | 8 |
| Scavenger receptor class A (SRCA) | 3 | 3 | 2 | 2 | 3 |
| Scavenger receptor class B (SRCB) | 15 | 18 | 11 | 13 | 14 |
| Scavenger receptor class C (SRCC) | 7 | 8 | 4 | 5 | 9 |
| Canonical effectors | |||||
| Attacin antimicrobial peptides (ATT) | 11 (12)* | 10 | 4 | 1 | 4 |
| Defensin antimicrobial peptides (DEF) | 5 (11)* | 5 | 0 | 4 | 1 |
| Diptericin antimicrobial peptides (DIPT) | 3 (1)* | 4 | 0 | 1 | 3 |
| Cecropin antimicrobial peptides (CEC) | 5 (10)* | 12 | 2 | 9 | 5 |
| Lysozymes (LYS) | 23 | 32 | 4 | 7 | 13 |
| Non-canonical effectors | |||||
| Thioredoxin peroxidases (TPX) | 5 | 6 | 6 | 5 | 8 |
| Prophenoloxidases (PPO) | 19 | 23 | 4 | 25 | 10 |
| Glutathione peroxidases (GPX) | 1 | 1 | 0 | 3 | 2 |
| Heme peroxidases (HPX) | 12 | 12 | 8 | 19 | 10 |
| Transferrins (TSF) | 4 | 6 | 3 | 5 | 3 |
*Numbers in parentheses are those numbers annotated after manual curation of the S. calcitrans genome. Scal: Stomoxys calcitrans, Mdom: Musca domestica, Gmor: Glossina morsitans, Aaeg: Aedes aegypti, Dmel: Drosophila melanogaster