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. 2021 Mar 10;12:170. doi: 10.1186/s13287-021-02206-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Skin recovery and evaluation of CON and DM after injury. a Image of representative wound and area of wound on different days. b HE staining of representative wound of CON and DM. c Masson staining of representative wound of CON and DM. d Evaluation of the thickness of epidermis and dermis in CON and DM. e Immunohistochemical staining of CD31 showed the number of endothelium blood vessels of the normal wound and DM wound at 7 days after healing. All data were expressed as the mean ± SEM. n = 3, * P < 0.05; **P < 0.01. DM, diabetic mice; CON, control mice; HE, hematoxylin eosin