Table 1.
Demographic and lung function data for the 4 study groups
| Lean Control | Lean Asthma | Obese Control | LONA Obese Asthma | P | |
|---|---|---|---|---|---|
| M/F | 3/7 | 2/8 | 1/6 | 2/6 | 0.88 |
| Age, yr | 42.4 ± 5.9 | 27.0 ± 7.8 | 43.0 ± 8.0 | 44.0 ± 7.6 | <0.01 |
| BMI, kg/m2 | 22.5 ± 1.5 | 23.3 ± 1.5 | 46.4 ± 2.9 | 44.1 ± 9.3 | <0.01 |
| FEV1, % | 98.2 ± 9.2 | 89.4 ± 17.5 | 99.0 ± 12.9 | 84.4 ± 13.8 | 0.11 |
| FVC, % | 103.8 ± 5.4 | 99.0 ± 15.4 | 96.0 ± 11.6 | 82.8 ± 8.2 | <0.01 |
| RV, % | 124.1 ± 29.7 | 135.1 ± 32.2 | 99.1 ± 38.3 | 100.8 ± 29.5 | 0.07 |
| TLC, % | 102.4 ± 8.6 | 99.1 ± 14.4 | 97.3 ± 14.3 | 90.8 ± 8.2 | 0.22 |
| FRC, % | 93.7 ± 22.7 | 99.3 ± 10.3 | 74.3 ± 13.7 | 76.6 ± 17.3 | <0.01 |
| ERV, % | 67.8 ± 37.6 | 64.2 ± 26.2 | 40.5 ± 45.3 | 33.0 ± 28.6 | 0.11 |
| PC20, mg/ml | 64 (22.2-64) | 2.8 (0.14–12.8) | 64 (64) | 1.47 (0.03–13.3) | <0.01 |
Values shown are means ± SD for normally distributed quantities, and median (range) for nonnormally distributed quantities. LONA, late-onset nonallergic; M/F, male/female; BMI, body mass index; FEV1, forced expiratory volume in 1 s; FVC, forced lung capacity; TLC, total lung capacity; PC20, concentration inducing a 20% fall in FEV1 from baseline; RV, residual volume; ERV, expiratory reserve volume.