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. 2021 Feb 24;12:615527. doi: 10.3389/fimmu.2021.615527

Figure 2.

Figure 2

Manhattan plot of meta-analysis GWAS with MPO-DNA levels of RS-I and RS-II. The Manhattan plot shows the statistical genetic association between SNPs and MPO-DNA complex levels. Each SNP is represented by a dot. Genomic coordinates are displayed along the x-axis and the negative log-base-10 of the p-value for each of the polymorphisms in the genome is displayed along the y-axis. The red line represents the genome-wide significance threshold (5 × 10−8). The SNPs with a suggestive association with MPO-DNA levels were annotated to the genes, KIF26B, CDK19, CATSPERB, AC027119.1.