Table 2.
Gene | MAF | Number of SNPs | p-value |
---|---|---|---|
OR10H1 | 0.003 | 6 | 4.48 × 10−9 |
RP11-461L13.5 | 0.003 | 3 | 1.32 × 10−7 |
RP11-24B19.4 | 0.003 | 3 | 1.93 × 10−9 |
RP11-461L13.3 | 0.005 | 6 | 2.44 × 10−7 |
KHDRBS1 | 0.005 | 7 | 3.12 × 10−7 |
ZNF200 | 0.004 | 5 | 3.49 × 10−7 |
RP11-395I6.1 | 0.001 | 3 | 3.51 × 10−7 |
RP11-696P8.2 | 0.002 | 4 | 3.78 × 10−7 |
RGPD1 | 0.014 | 12 | 7.58 × 10−7 |
AC007036.5 | 0.002 | 4 | 1.05 × 10−6 |
RPL21† | 0.003 | 6 | 1.10 × 10−6 |
SNORA27† | 0.003 | 6 | 1.10 × 10−6 |
SNORD102† | 0.003 | 6 | 1.10 × 10−6 |
TMEM55B† | 0.019 | 21 | 1.15 × 10−6 |
ZDHHC19† | 0.008 | 10 | 1.52 × 10−6 |
RTN4R† | 0.011 | 15 | 1.77 × 10−6 |
FOXC1† | 0.004 | 5 | 2.62 × 10−6 |
Genes found through exome sequencing analysis that are associated with MPO-DNA complex levels.
The significance threshold for gene-based analysis set at p-value < 1.07 × 10−6. †Genes with a suggestive association with MPO-DNA complex levels. MAF, minor allele frequency; SNP, single-nucleotide polymorphism.