Table 2.
Multivariable repeated-measure linear regression model of CIPN8 with previously published clinical variables[25] and vitamin D.
| Description | Fixed Effect | Coefficient Estimate | Standard Deviation | P-value |
|---|---|---|---|---|
| Model 1 N=37 | Baseline CIPN8 | 0.21 | 0.04 | <0.0001 |
| Cumulative dose | 0.48 | 0.06 | <0.0001 | |
| Relative dose intensity | 0.26 | 0.93 | 0.78 | |
| Age | 0.01 | 0.01 | 0.27 | |
| Alcohol vs. none | 0.46 | 0.23 | 0.05 | |
| Diabetes vs. no diabetes | 0.35 | 0.30 | 0.24 | |
| Vitamin D deficiency vs. nota | 0.40 | 0.25 | 0.11 | |
| Model 2 N=37 | Baseline CIPN8 | 0.21 | 0.04 | <0.0001 |
| Cumulative dose | 0.48 | 0.06 | <0.0001 | |
| Relative dose intensity | 0.10 | 0.93 | 0.91 | |
| Age | 0.01 | 0.01 | 0.24 | |
| Alcohol vs. none | 0.48 | 0.23 | 0.04 | |
| Diabetes vs. no diabetes | 0.28 | 0.29 | 0.33 | |
| Vitamin D level (ng/mL) | −0.04 | 0.02 | 0.02 |
a
Vitamin D deficiency defined as < 20 ng/mL. Acronyms: CIPN8, Scaled score (range 0–100) of the 8-item sensory subscale of EORTC chemotherapy induced peripheral neuropathy 20 (CIPN20) questionnaire.