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. 2021 Mar 10;40:92. doi: 10.1186/s13046-021-01889-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — ZNF582-AS1 overexpression decreased rRNA adenine N(6)-methyltransferase A8K0B9 expression. a The overexpression efficiency of ZNF582-AS1 in OSRC2 cells. b iTRAQ results showed that 69 proteins were downregulated and 75 proteins were upregulated in ZNF582-AS1-overexpressed OSRC2 cells compared with control OSRC2 cells. c The expression of these 144 differently expressed proteins in ZNF582-AS1-overexpressed OSRC2 cells and control cells. d Biological Process GO term enrichment analysis of the complete 144 statistically significant proteins. e and f Validation of the presence of A8K0B9 protein. g A8K0B9 expression was decreased in ZNF582-AS1-overexpressed OSRC2 cells compared with control cells. h Changes of A8K0B9 protein level in OSRC2 cells after transient transfection of different doses of ZNF582-AS1 overexpression plasmid. i Estimation of the binding propensity of A8K0B9-ZNF582-AS1 pair. j RNA pull-down assay indicated that A8K0B9 protein bound specifically to ZNF582-AS1