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. 2021 Mar 10;21:162. doi: 10.1186/s12935-021-01861-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Identification of unique serum proteins in T2DM patients with LAC. a–c Volcano plot showing the DEPs in the T2DM, LAC and T2DM + LAC patients compared to healthy controls. d Venn diagram of the 70 differentially expressed proteins in the serum samples from the four comparisons (T2DM vs. NC, LAC vs. NC and T2DM + LAC vs. NC). In total, 13 proteins were specifically expressed in the T2DM + LAC group. e Hierarchical cluster analysis of the 70 DEPs in the NC, T2DM, LAC, and T2DM + LAC serum samples. Note: There were five samples in each group. Pseudocolors indicate differential expression (red, upregulation; blue, downregulation)