Table 5.
Down-regulated lncRNAs in neuroblastoma (NB, Neuroblastoma; OS, overall survival; EFS, event-free survival).
| lncRNA | Specimens | Cell line | Targets/regulators | Signaling pathway | Function | Effect of lncRNA down-regulation on patient’s prognosis | Reference |
|---|---|---|---|---|---|---|---|
| NR_120420 | – | SH-SY5Y | P65, ERK, AKT | NF-κB | The knock-down of NR_120420 enhances cell viability but reduces the apoptosis. | – | (125) |
| CASC15 | 220 high-risk NB samples | SK-N-BE2, SK-N-SH | NEUROD1, NEDD9, NEUROG2 | – | CASC15 depletion improves proliferation and invasive capabilities and shifts the NB gene expression away from the differentiated neural phenotype. | Lower OS | (126) |
| Two cohorts: one with 59 and the other with 498 NB patients | SHSY-5Y, SK-N-AS, IMR32, SK-N-BE2, hESCs, HEK293T | SOX9, CHD7, USP36 | – | These lncRNAs regulate SOX9 expression through regulation of CHD7 stability. Loss of this synergy between these lncRNAs enhances proliferation, migration, invasion, colony formation of NB cells. | Poor OS and EFS | (127) | |
| NBAT1 | |||||||
| FOXD3-AS1 | 42 NB tumor samples, GSE16476 dataset: 88 cases of NB |
NB-1643, SK-N-BE(2), NB-1691, IMR32, BE(2)-C, SK-N-AS, SH-SY5Y, SK-N-SH |
PARP1, CTCF | – | Over-expression of FOXD3-AS1 promotes neuronal differentiation and reduces aggressive behavior of these cells. | Poor survival | (128) |
| MEG3 | Tumor and para-tumor tissue samples (n = 6) | BE(2)-C | PMAIP1, BID, HIF-1α | – | MEG3 overexpression reduces proliferation and elevates apoptosis rate. | – | (114) |
| Linc-NeD125 | – | BE(2)-C, D283Med, NB4, HL-60 | BCL-2 | – | Linc-NeD125 is the host gene of miR-125b-1. Its down-regulation reduces cell proliferation and activates the antiapoptotic factor BCL-2. | – | (129) |
| MYCNOS | – | Lan6 | MYCN, MAP4, G3BP1, FKBP3 | – | MYCNOS RNA localizes to the MYCN promoter and reduces its expression. | – | (130) |
| CASC15-S | NCI TARGET project: 108 NB patients | SK-N-BE2, SK-N-SH, HEK293T | ALCAM, NEUROD1, NEDD9, NEUROG2 | – | Attenuating CASC15-S elevates cellular proliferation, proliferation, invasion, and migratory capacity. CASC15-S regulates genes involved in neural crest development. | Poor OS | (126) |
| NBAT-1 | 15 NB snap-frozen tumors, 108 patients and RNA-seq data of 498 patients | SK-N-FI, SH-SY5Y, SK-N-AS, SK-N-BE(2) | NRSF, REST, SOX9, VCAN, EZH2 | – | NBAT-1 down-regulation boosts cellular proliferation and invasion and inhibits neuronal differentiation. | Poor survival | (85) |
| CASC7 | 48 NB patients | LAN-2 | miR-10a, PTEN | – | CASC7 overexpression decreases the proliferation of NB cells. | – | (131) |
| KCNQ1OT1 | Xena datahub: 128 NB tissues | SH-SY5Y, IMR32, HEK293T | miR-296-5p, Bax | – | KCNQ1OT1 acts as a sponge for miR-296-5p. miR-296-5p inhibits Bax protein and cell apoptosis. | – | (132) |
| NEAT1 | 30 NB tissues | SKN-SH, SH-SY5Y, IMR-32, SH-N-AS | miR-183-5p, FOXP1 | ERK/AKT | NEAT1 up-regulation lowers cell proliferation, migration, and invasion rates. | – | (133) |