Table 6.
Prognostic value of lncRNAs in neuroblastoma (NB, neuroblastoma; OS, overall survival; EFS, event-free survival).
| Sample number | Kaplan–Meier analysis | Multivariate cox regression | Reference |
|---|---|---|---|
| Two groups of 35 patients, each expressing low and high levels of DLX6AS1 | High DLX6-AS1 expression correlates with a low OS rate of NB patients. | – | (90) |
| EQC-RPM-seqcnb1 dataset: 246 low and 247 high expression groups of lncNB1 | High levels of lncNB1 correlate with poor prognosis. | – | (92) |
| Genomics Analysis and Visualization Platform for NB dataset: Two groups of high (=21) and low (=67) for LINC01296 expression | High LINC01296 expression is associated with poor outcome. | – | (94) |
| GSE62564 dataset: two groups of low and high expression for SNHG16 expression, each containing 249 patients | High levels of SNHG16 expression correlates with lower EFS and OS. | – | (95) |
| High (=34) and low (=10) expressing groups of RMRP lncRNA | Higher RMRP expression relates to poor prognosis and survival. | – | (104) |
| GAU1 expression in two groups from TCGA dataset: high (=44) and low (=44) | High GAU1 expression correlates with lower OS. | – | (107) |
| GALNT8 expression in two groups from TCGA dataset: high (=13) and low (=75) | Higher GALNT8 levels correlate with poor OS. | ||
| CASC15 expression: Cohort a: high (=29) and low (=30) expression groups Cohort b: high and low groups, each containing 249 patients |
Lower levels of CASC15 expression correlate with lower OS and EFS. | Both CASC15-003 and CASC15-004 predict OS and EFS. | (127) |
|
GSE16476 dataset: 88 NB cases, expressing high (=22) and low (=66) levels of FOXD3-AS1 42 NB patients expressing high (=19) and low (23) levels of FOXD3-AS1 |
Lower expression levels of FOXD3-AS1 correlate with lower OS. | FOXD3-AS1 is a possible independent prognostic factor. | (128) |
| pancEts-1 expression: 42 NB patients (low=23, high=19) and 88 NB cases (low=50, high=38) from GSE16476 dataset |
Higher levels of pancEts-1 negatively correlate with survival rate. | Patients’ age, MYCN amplification, INSS stage, pancEts-1 expression, and hnRNPK expression, but not gender, are independent prognostic factors for poor outcome. | (109) |
| SNHG1 expression in GSE62564 dataset: 246 low and 247 high, GSE16476 dataset: 44 low and 44 high | Higher expression levels of SNHG1 negatively correlate with OS and EFS. | SNHG1 high expression is a significant low hazard rate indicator for both OS and EFS. | (106) |
| CAI2 expression in NB patients: high=19, low=43 | CAI2 expression negatively correlates with OS and EFS. | – | (87) |
| NBAT-1 expression in 2 cohorts: 1) 50 high and 43 low, 2) 314 high and 184 low | NBAT expression significantly correlates with OS and EFS. | NBAT-1 is an independent prognostic marker in predicting EFS. | (85) |
| lncUSMycN expression: Versteeg dataset: 79 low and 9 high, Kocak dataset: 429 low and 47 high | High levels of lncUSMycN expression have been linked with poor survival. | High levels of lncUSMycN and NonO expression in are linked with poor OS, independent of disease stage, age at diagnosis, and MYCN amplification. | (86) |
| CASC15-S expression in NB patients: low=163, high 87 | Higher levels of CASC15-S significantly correlate with longer OS in NB patients. | – | (126) |
| CASC15-S expression: 163 low, 87 high | CASC15-S expression in NB patients significantly correlates with OS. | CASC15-S expression is correlated with more aggressive features and lower OS. | (126) |
| CASC11 expression in NB patients: 21 high and 21 low | CASC11 expression negatively correlates with the survival rate. | – | (120) |
| DUXAP8 expression in two groups: group 1: 1 + 2+4S stage (n = 18) and group 2: 3 + 4 stage (n = 27) | The survival rate is low in high expression of the DUXAP8 group compared with lower expression of the DUXAP8 group. | – | (121) |
| SNHG7 expression level in NB patients: 25 high and 20 low | SNHG7 expression levels negatively correlate with the OS rate. | – | (103) |
| NHEG1 expression: GSE62564 dataset: 498 patients (432=low, 66=high), 42 primary NB cases and 21 normal dorsal ganglia | NHEG1 expression negatively correlates with OS and EFS rates. | NHEG1 expression has a significant prognostic value for NB patients. | (123) |
| SNHG16 expression in NB patients: high=22, low=23 | SNHG expression levels negatively correlates with OS. | – | (99) |