Table 7.

List of circRNAs dysregulated in neuroblastoma.

circRNA	Pattern of expression	Samples	Cell line	Targets/regulators	Function	Patient’s prognosis	Reference
circDGKB	↑	30 NB tissues and 10 normal dorsal root ganglia as controls	SK-N-SH, SH-SY5Y	miR-873, GLI1, ZEB1	circDGKB up-regulation improves the proliferation, migration, invasion, and tumorigenesis, though it reduces cell apoptosis.	Lower OS	(135)
circ-CUX1	↑	54 NB patients, GSE16476 dataset: 88 NB patients, oncogenomic database: 117 NB and 3 normal tissues	MCF 10A, HeLa, SH-SY5Y, IMR32, SK-N-AS, BE(2)-C, SK-NMC, LoVo, PC-3, HEK293, HEK293T	EWSR1, MAZ, CUX1	circ-CUX1 knock-down inhibits aerobic glycolysis, proliferation, progression, and aggressiveness of NB. circ-CUX1 binds to EWSR1 to enable its contact with MAZ, leading to transactivation of MAZ and transcriptional modification of CUX1 and other genes linked with cancer progression.	Lower survival rate	(136)