Figure 3.

Heatmap of most significantly differentially expressed genes. Heatmap showing the relative expression of the 50 most significantly differentially expressed genes (DEGs) of the 263 significant DEGs identified through the meta-analysis, where 182 genes were co-up-regulated, and 81 genes were co-down-regulated (case versus control). The heatmap indicates the normalized expression value of each DEG in the individual samples, and genes were clustered based on their condition (cases vs controls) and their original datasets. The heatmap was created by the visualization module in NetworkAnalyst, where genes with p-value < 0.05 in the Random Effect Model analysis were considered significant.