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. 2021 Feb 24;12:624117. doi: 10.3389/fimmu.2021.624117

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Copyright © 2021 Badr, Omar and Häcker

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interactions between signature derived genes and genome-wide-associated and cancer driver genes. The genes of the 55-gene signature were integrated with 37 GWAS and 61 cancer driver genes in NetworkAnalyst tools to visualize gene interactions. A “zero order” interaction network with 49 nodes and 81 edges was used. The most highly ranked nodes across the dataset based on network topology measures were TP53 (betweenness centrality = 468.99), and CTNNB1 (betweenness centrality = 450.38). TNFRSF10B (betweenness centrality = 32.53) ranked the highest among the gene signature and MUC1 (betweenness centrality = 43.66) among GWAS genes. (Red = up-regulated DEGs; Blue = down-regulated DEGs; Green = GWAS; Purple = OncoGene).