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. 2021 Feb 24;12:619568. doi: 10.3389/fendo.2021.619568

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Copyright © 2021 van der Spoel, Roelfsema and van Heemst

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of a fictional 24-h thyroid-stimulating hormone (TSH) concentration profile (top) and secretion rate (bottom). The top figure represents an example of a 24-h TSH concentration profile starting at 09:00 h. A pulse and the mode of one pulse, which is the time it takes before the pulse reaches its maximum, are indicated. The bottom figure is a schematic representation of an example of the secretion rate, which can be determined by deconvolution analysis. The basal tonic (or non-pulsatile) secretion and the pulsatile secretion together contribute to the total TSH secretion.