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. 2021 Feb 24;12:619568. doi: 10.3389/fendo.2021.619568

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Copyright © 2021 van der Spoel, Roelfsema and van Heemst

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of a fictional 24-h thyroid-stimulating hormone (TSH) concentration profile with cosinor model parameters. A cosinor model with its parameters is drawn on the same fictional 24-h TSH concentration profile of Figure 1 to illustrate the circadian rhythm of TSH. Cosinor analysis calculates the midline estimating statistic of rhythm (MESOR), which is a circadian rhythm-adjusted mean, the maximum, the nadir (minimum), the amplitude, and the acrophase, which is the time at which the cosinor model reaches its maximal value.