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. 2021 Feb 24;12:618582. doi: 10.3389/fphys.2021.618582

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Copyright © 2021 Saoudi, Badraoui, Rahmouni, Jamoussi and El Feki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological observation of rat hepatic tissue of control, ACEO, chlorpyrifos, and vitamin C stained with hematoxylin and eosin viewed at original magnification (×400). (A) Control liver showing normal architecture; (B) ACEO alone administered rats showing normal architecture in liver tissue; (C) CPF liver sections showed abnormal cellular morphology accompanied by sinusoidal dilatation, congestion, ballooning, necrosis, vacuole formations, and degeneration of hepatocytes after chlorpyrifos treatment; (D) ACEO + CPF co-treated rats indicating protected hepatic tissue; (E) VitC alone treated rats showed normal architecture in liver tissue; and (F) VitC + CPF showed that vitamin C co-administration restored liver tissue alteration induced by chlorpyrifos.