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. 2021 Feb 24;12:618582. doi: 10.3389/fphys.2021.618582

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Copyright © 2021 Saoudi, Badraoui, Rahmouni, Jamoussi and El Feki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological observation of renal tissue of control, ACEO, chlorpyrifos, and vitamin C stained with hematoxylin and eosin viewed at original magnification (×400). (A) Control kidney showing normal architecture; (B) ACEO alone administered rats showing normal architecture in renal tissue; (C) CPF kidney sections revealed tubular epithelial degenerations, focal necrosis of renal tubules, vacuole formations and reduction of glomerular space after chlorpyrifos treatment; (D) ACEO + CPF showed that ACEO co-administration restored renal tissue alteration induced by chlorpyrifos; (E) VitC alone treated rats showed normal architecture in kidney tissue; and (F) VitC + CPF showed that vitamin C co-administration restored renal tissue damage induced by chlorpyrifos.