TABLE 5.

The severity of the reaction in liver and kidney tissue of control and treated rats with chlorpyrifos, Artemisia campestris essential oil (ACEO), vitamin C, and their combination (ACEO + CPF and VitC + CPF).

Histopathological alterations	Experimental groups
	Control	ACEO	CPF	ACEO + CPF	VitC	VitC + CPF
Liver
Sinusoidal dilatation	–	–	++	–	–	–
Congestion of central vein	–	–	+	+	–	+
Ballooning degeneration of hepatocytes	–	–	++	+	–	–
Necrosis	–	–	+	–	–	–
Vacuole formations	–	–	++	–	–	+
Kidneys
Epithelial degenerations	–	–	++	+	–	–
Focal necrosis of renal tubules	–	–	++	–	–	+
Vacuole formations	–	–	+	+	–	+
Reduction of glomerular space	–	–	+	–	–	–

+++ Severe; ++ moderate; + mild; – nil.