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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Matter. 2021 Jan 6;4(1):26–53. doi: 10.1016/j.matt.2020.10.002

Figure 2. Drug Release Driven by the Cascade of Stimuli-Induced Heating and Heat-Induced Linker Cleavage.

Figure 2.

(A) Schematic illustration of light-triggered drug-release process.

(B) Temperature elevation profiles of CPT@DOX-UCST/PPy upon laser irradiation.

(C) Size change of UCST/PPy at different temperatures for four cycles.

(D) In vitro drug-release behaviors of CPT and DOX from CPT@DOX-UCST/PPy at different temperatures.

(E) In vitro drug-release behaviors of CPT and DOX from CPT@DOX-UCST/PPy with periodic laser irradiation (808 nm, 2 W cm−2).

(F) Intracellular drug release of CPT@DOX-UCST/PPy treated without (−) or with (+) light irradiation (808 nm, 2 W cm−2, 5 min).

Reproduced with permission from Yang et al.30 Copyright 2018, Elsevier.