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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Matter. 2021 Jan 6;4(1):26–53. doi: 10.1016/j.matt.2020.10.002

Figure 6. Drug Release Driven by the Cascade of Stimuli-Induced Hypoxia and Hypoxia-Induced Linker Cleavage.

Figure 6.

(A) Schematic illustration of hypoxia-responsive mechanism of CPs-CPT-Ce6 NPs.

(B) Intracellular hypoxia detection of HeLa cells with different treatments.

(C) Fluorescence images of HeLa cells incubated with CPs-CPT-Ce6 NPs.

(F) Viability of HeLa cells with different treatments and laser irradiation. (***p < 0.001).

(A) to (D) reproduced with permission from Zhang et al.40 Copyright 2018, American Chemical Society.

(E) Schematic illustration showing the hypoxia-activated drug release from SPNpd.

(F) HPLC profiles of free IPM-Br, NADH and SPNpd incubated with NTR and NADH.

(G and H) Viabilities of 4T1 cells incubated with SPNpd and SPNc with or without laser irradiation in normoxic (G) and hypoxic (H) conditions. (E) to (H) reproduced with permission from Cui et al.41 Copyright 2019, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.