Fig. 1.

Schematic diagram to illustrate how in theory the 8 principles (identified by digits) might enhance CNS drug discovery (when applied in the sequence indicated by arrows, from left to right). Basic neuroscience feeds into the definition of disease phenotypes that define targets, and the generation of disease-relevant perturbations. Test molecules are generated from a variety of platforms including medicinal chemistry. Molecules are tested in animal and humans using translational methods and paradigms. Targets are validated and clinical efficacy tested via collaborative studies. Results of studies are fed back to validate, or otherwise, the methods employed, or the molecule tested, or its clinical target