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. 2021 Mar 10;238(6):1417–1436. doi: 10.1007/s00213-021-05787-x

Fig. 2.

Fig. 2

Schematic diagram to illustrate how in practice the 8 principles (identified by digits), applied in the sequence identified by arrows, might enhance CNS drug discovery, in the case of a specific example, drugs to enhance cognition in schizophrenia. See legend to Fig. 1 for further description. Not all medications would necessarily require deployment of all 8 principles