Table 3:
Adjusted Hazards Ratio of Cardiovascular Events Across Diastolic Blood Pressure and NT-proBNP Categories, ARIC Study (1996–1998, Visit 4)
| DBP, mmHg | NT-Pro-BNP | P trend‡ | |||||
|---|---|---|---|---|---|---|---|
| <100 pg/mL | ≥100 to <300 pg/mL | ≥300 pg/mL | |||||
| n/N (event rate*) | HR (95% CI)† | n/N (event rate*) | HR (95% CI)† | n/N (event rate*) | H (95% CI)† | ||
| Cardiovascular disease (CVD) | |||||||
| <60 | 173/654 (18.94) | 1.24 (1.04–1.47) | 104/353 (21.94) | 1.60 (1.28–1.98) | 36/72 (51.37) | 3.13 (2.21–4.43) | <0.0001 |
| 60–69 | 427/2061 (14.30) | 0.97 (0.85–1.10) | 216/816 (19.88) | 1.50 (1.27–1.77) | 77/148 (51.09) | 3.51 (2.75–4.49) | <0.0001 |
| 70–79 | 557/2441 (15.63) | Ref | 242/848 (20.74) | 1.54 (1.32–1.80) | 71/137 (47.23) | 3.24 (2.52–4.17) | <0.0001 |
| 80–89 | 221/1030 (14.72) | 0.93 (0.79–1.09) | 135/357 (29.30) | 2.02 (1.67–2.44) | 48/92 (53.38) | 3.16 (2.34–4.26) | <0.0001 |
| ≥90 | 50/175 (20.08) | 1.26 (0.94–1.69) | 42/96 (33.60) | 2.19 (1.60–3.01) | 17/29 (65.64) | 2.49 (1.52–4.07) | 0.009 |
| P trend | 0.02 | 0.06 | 0.95 | ||||
| Heart Failure hospitalization | |||||||
| <60 | 94/654 (9.74) | 1.39 (1.10–1.77) | 72/353 (14.51) | 2.04 (1.55–2.68) | 28/72 (38.73) | 4.83 (3.24–7.20) | <0.0001 |
| 60–69 | 198/2061 (6.28) | 0.96 (0.79–1.15) | 130/816 (11.31) | 1.80 (1.45–2.24) | 62/148 (38.43) | 5.13 (3.84–6.84) | <0.0001 |
| 70–79 | 270/2441 (7.18) | Ref | 154/848 (12.53) | 1.93 (1.57–2.37) | 55/137 (33.90) | 5.23 (3.88–7.05) | <0.0001 |
| 80–89 | 92/1030 (5.80) | 0.83 (0.65–1.06) | 82/357 (16.50) | 2.35 (1.83–3.01) | 31/92 (33.09) | 3.52 (2.41–5.13) | <0.0001 |
| ≥90 | 21/175 (7.92) | 1.01 (0.65–1.58) | 27/96 (20.34) | 2.67 (1.79–3.98) | 12/29 (45.13) | 4.21 (2.33–7.61) | <0.0001 |
| P-trend | 0.03 | 0.31 | 0.84 | ||||
| Coronary heart disease (CHD) | |||||||
| <60 | 103/654 (11.07) | 1.25 (1.00–1.57) | 49/353 (10.02) | 1.34 (0.98–1.83) | 17/72 (22.27) | 2.40 (1.44–4.00) | 0.08 |
| 60–69 | 273/2061 (8.99) | 1.03 (0.88–1.21) | 117/816 (10.40) | 1.42 (1.14–1.77) | 34/148 (20.21) | 2.20 (1.53–3.16) | <0.0001 |
| 70–79 | 328/2441 (9.05) | Ref | 126/848 (10.45) | 1.44 (1.17–1.78) | 33/137 (20.25) | 2.30 (1.60–3.31) | <0.0001 |
| 80–89 | 131/1030 (8.59) | 0.93 (0.76–1.14) | 74/357 (15.33) | 1.89 (1.46–2.43) | 20/92 (19.90) | 2.29 (1.45–3.61) | <0.0001 |
| ≥90 | 29/175 (11.40) | 1.31 (0.89–1.92) | 18/96 (13.60) | 1.63 (1.01–2.63) | 7/29 (24.54) | 1.35 (0.63–2.88) | 0.94 |
| P-trend | 0.15 | 0.57 | 0.80 | ||||
| Ischemic stroke | |||||||
| <60 | 31/654 (3.13) | 1.08 (0.72–1.62) | 20/353 (3.93) | 1.41 (0.86–2.31) | 7/72 (8.77) | 2.75 (1.26–5.99) | 0.17 |
| 60–69 | 71/2061 (2.22) | 0.83 (0.62–1.13) | 39/816 (3.27) | 1.24 (0.85–1.81) | 21/148 (11.83) | 3.95 (2.42–6.42) | <0.0001 |
| 70–79 | 107/2441 (2.81) | Ref | 57/848 (4.51) | 1.75 (1.26–2.44) | 13/137 (7.26) | 2.52 (1.40–4.54) | 0.0009 |
| 80–89 | 52/1030 (3.26) | 1.20 (0.86–1.67) | 35/357 (6.80) | 2.50 (1.70–3.67) | 17/92 (17.00) | 5.00 (2.97–8.44) | <0.0001 |
| ≥90 | 14/175 (5.31) | 1.86 (1.06–3.26) | 9/96 (6.47) | 2.10 (1.06–4.16) | 7/29 (24.13) | 5.00 (2.27–11.02) | 0.02 |
| P-trend | 0.06 | 0.11 | 0.11 | ||||
| CV Mortality | |||||||
| <60 | 88/654 (8.80) | 1.54 (1.20–1.99) | 62/353 (11.91) | 2.00 (1.49–2.68) | 28/72 (34.86) | 5.44 (3.60–8.21) | <0.0001 |
| 60–69 | 179/2061 (5.55) | 1.07 (0.88–1.31) | 118/816 (9.80) | 1.95 (1.54–2.45) | 56/148 (29.98) | 4.52 (3.33–6.15) | <0.0001 |
| 70–79 | 214/2441 (5.54) | Ref | 122/848 (9.43) | 1.80 (1.43–2.26) | 51/137 (27.55) | 4.69 (3.42–6.42) | <0.0001 |
| 80–89 | 81/1030 (4.99) | 0.92 (0.71–1.19) | 63/357 (11.81) | 2.15 (1.62–2.86) | 30/92 (27.58) | 3.69 (2.50–5.45) | <0.0001 |
| ≥90 | 22/175 (8.05) | 1.38 (0.89–2.15) | 26/96 (18.30) | 3.31 (2.20–5.00) | 14/29 (44.67) | 4.59 (2.64–7.96) | 0.0012 |
| P-trend | 0.0064 | 0.1560 | 0.8733 | ||||
| All-cause Mortality | |||||||
| <60 | 209/654 (20.90) | 1.37 (1.16–1.61) | 128/353 (24.59) | 1.49 (1.22–1.83) | 50/72 (62.25) | 3.63 (2.69–4.90) | <0.0001 |
| 60–69 | 505/2061 (15.65) | 1.15 (1.02–1.30) | 282/816 (23.41) | 1.65 (1.42–1.92) | 86/148 (46.05) | 2.81 (2.22–3.55) | <0.0001 |
| 70–79 | 525/2441 (13.60) | Ref | 248/848 (19.16) | 1.35 (1.16–1.58) | 78/137 (42.14) | 2.64 (2.07–3.37) | <0.0001 |
| 80–89 | 234/1030 (14.42) | 1.11 (0.95–1.30) | 125/357 (23.43) | 1.68 (1.38–2.05) | 49/92 (45.04) | 2.60 (1.94–3.50) | <0.0001 |
| ≥90 | 52/175 (19.03) | 1.54 (1.15–2.05) | 40/96 (28.15) | 2.11 (1.53–2.92) | 19/29 (60.62) | 3.15 (1.98–4.99) | 0.0380 |
| P-trend | 0.0007 | 0.0623 | 0.5453 | ||||
Significant values in bold.
*
Event rates per 1000 person-years
†
Cox Model adjusted for: age, race, gender, body mass index, smoking status, hypertension medication use, use of cholesterol-lowering medication diagnosed diabetes, glucose, total cholesterol/ HDL-cholesterol ratio, estimated glomerular filtration rate in mL/min/1.73m2.
p trends for hazard ratios of proportional hazard regression models were calculated based on the results of Wald chi-square test on linearity hypothesis of ordered NT-proBNP or DBP categories.
Abbreviations: CI indicated confidence interval; CV=cardiovascular; HR: adjusted Hazard Ratio; SBP: systolic blood pressure; n: number of events, N: number of persons at risk