Table 1.
Comparison of clinical characteristics between eGFR slope ≧ –3 and < –3 mL/min/1.73m2/yr.
| Characteristics | All (n = 419) | eGFR slope ≧ –3 (n = 304) | eGFR slope < –3 (n = 115) | p |
|---|---|---|---|---|
| Age (year) | 65.9 ± 12.3 | 67.0 ± 11.9 | 63.1 ± 13.0 | .003 |
| Male gender (%) | 61.1 | 65.1 | 50.4 | .006 |
| Smoking (%) | 30.5 | 29.6 | 33.0 | .495 |
| Diabetes mellitus (%) | 56.6 | 49.3 | 75.7 | <.001 |
| Hypertension (%) | 83.1 | 80.3 | 90.4 | .013 |
| Coronary artery disease (%) | 11.2 | 8.9 | 17.4 | .014 |
| Systolic blood pressure (mmHg) | 141.4 ± 21.1 | 138.7 ± 19.5 | 148.3 ± 23.5 | <.001 |
| Diastolic blood pressure (mmHg) | 79.5 ± 12.8 | 79.2 ± 12.2 | 80.1 ± 14.3 | .552 |
| Laboratory parameters | ||||
| Fasting glucose (mg/dL) | 126.4 ± 57.7 | 119.8 ± 45.2 | 143.6 ± 79.6 | .003 |
| Triglyceride (mg/dL) | 140.5 (96–200.75) | 132 (90.5–191.5) | 164 (118–240) | <.001 |
| Total cholesterol (mg/dL) | 194.5 ± 46.1 | 190.5 ± 43.6 | 205.1 ± 50.6 | .004 |
| Hemoglobin (g/dL) | 11.7 ± 2.3 | 12.1 ± 2.3 | 10.7 ± 2.0 | <.001 |
| Baseline eGFR (mL/min/1.73m2) | 26.4 ± 14.1 | 29.3 ± 14.2 | 18.9 ± 10.7 | <.001 |
| Calcium-phosphorous product (mg2/dL2) | 38.0 ± 8.6 | 37.2 ± 8.2 | 40.1 ± 9.1 | .002 |
| Echocardiographic parameters | ||||
| LAD (cm) | 3.7 ± 0.6 | 3.7 ± 0.6 | 4.0 ± 0.6 | <.001 |
| LAD ≧ 4.7 cm (%) | 5.3 | 3.3 | 10.4 | .003 |
| LVM/BSA (g/m2) | 116.8 ± 36.6 | 112.0 ± 34.9 | 129.7 ± 37.9 | <.001 |
| LVM/BSA > 115 g/m2 in male and > 95 g/m2 in female (%) | 56.6 | 49.7 | 74.8 | <.001 |
| LVM/ht2.7 (g/ht2.7) | 55.0 ± 18.3 | 52.3 ± 17.3 | 62.0 ± 19.0 | <.001 |
| LVM/ht2.7 > 48 g/ht2.7 in male and > 44 g/ht2.7 in female (%) | 64.9 | 59.5 | 79.1 | <.001 |
| o/p LVM (%) | 153.3 ± 49.6 | 148.3 ± 46.1 | 166.2 ± 55.7 | .001 |
| o/p LVM > 128% (%) | 68.1 | 64.6 | 77.0 | .016 |
| LVEF (%) | 69.2 ± 10.0 | 69.6 ± 9.9 | 68.1 ± 10.2 | .171 |
| LVEF < 50% (%) | 4.1 | 3.9 | 4.3 | .853 |
| Outcome | ||||
| eGFR slope (mL/min/1.73 m2/yr) | –2.01 ± 0.15 | –0.57 ± 0.09 | –5.81 ± 0.27 | <.001 |
| Progression to dialysis (%) | 39.6 | 27.0 | 73.0 | <.001 |
eGFR: estimated glomerular filtration rate; LAD: left atrial dimension; LVM: left ventricular mass; BSA: body surface area; ht: height; o/p: observed/predicted; LVEF: left ventricular ejection fraction.