Table 2.
Subgroup analyses with regard to the association between various hematuria and end-stage renal disease.
| Classification | Study no. | Patient no. | RR (95% CI) | p Value | I^2 |
|---|---|---|---|---|---|
| Initial hematuria | 7 | 3940 | 1.32 (0.87, 2.00) | .190 | 72% |
| hematuria | 3 | 377 | 0.79 (0.44, 1.42) | .434 | 36.7% |
| Microscopic hematuria | 4 | 3563 | 1.87 (1.40, 2.50) | <.001 | 23.7% |
| At biopsy | 5 | 3293 | 1.21 (0.69, 2.12) | .503 | 79.1% |
| Disease onset | 2 | 647 | 1.63 (0.90, 2.93) | .107 | 38.5% |
| Europe and America | 6 | 1657 | 1.16 (0.78, 1.74) | .468 | 56.5% |
| Proteinuria > 1 g/d | 3 | 393 | 1.01 (0.73, 1.39) | .962 | 0% |
| EGFR < 60 ml/min/1.73m2 | 2 | 183 | 0.99 (0.70, 1.41) | .961 | 0% |
| Initial macroscopic hematuria | 7 | 5158 | 0.68 (0.58, 0.79) | <.001 | 12.2% |
| At biopsy | 5 | 3894 | 0.68 (0.57, 0.82) | <.001 | 23.2% |
| Before biopsy | 2 | 1264 | 0.60 (0.41, 0.87) | .008 | 0% |
| Aisa | 4 | 4890 | 0.59 (0.46, 0.76) | <.001 | 0% |
| Europe and USA | 3 | 268 | 0.70 (0.56, 0.89) | .003 | 32.2% |
| Proteinuria > 1 g/d | 5 | 3915 | 0.64 (0.52, 0.80) | <.001 | 39.5% |
| Proteinuria < 1 g/d | 2 | 1243 | 0.67 (0.44, 1.00) | .052 | 0% |
| EGFR > 60 ml/min/1.73m2 | 5 | 2766 | 0.73 (0.64, 0.83) | <.001 | 0% |
CI: confidence interval; eGFR: estimated glomerular filtration rate; RR: risk ratio.